高福[中国科学院院士、中国疾控中心副主任]简介_高福[中国科学院院士、中国疾控中心副主任]个人资料_高福[中国科学院院士、中国疾控中心副主任]微博_百科网
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高福[中国科学院院士、中国疾控中心副主任]简介_高福[中国科学院院士、中国疾控中心副主任]个人资料_高福[中国科学院院士、中国疾控中心副主任]微博

2016-12-02 02:07:37 科学百科 阅读 2 次

教育背景/高福[中国科学院院士、中国疾控中心副主任] 编辑

高福[中国科学院院士、中国疾控中心副主任]
高福

1979-1983,山西农业大学,学士,兽医学。
1983-1986,北京农业大学(现中国农业大学),硕士,微生物学与动物传染病学。
1991-1994年,英国牛津大学博士(DPhil-Oxon)(师从David H L Bishop,Ernest A Gould),生物化学
1994年(3个月)加拿大Calgary University(卡尔加里大学)博士后(师从Robert Bell)
1995-1998年,英国牛津大学博士后(师从John I bell,Andrew J McMichael,Bent K Jakobsen) 
1999-2001年,美国哈佛大学/哈佛医学院博士后(师从Don C Wiley,Stephen C Harrison)(工作期间资助:英国Wellcome Trust International Travelling Fellow)
2001-2004年,英国牛津大学讲师、博士生导师、Group leader

工作经历/高福[中国科学院院士、中国疾控中心副主任] 编辑

1986-1991 年 北京农业大学 助教 / 讲师 1994 年(3个月) 加拿大 Calgary University 博士后(师从 Robert Bell )

1995-1998 年 英国牛津大学 博士后(师从 John I bell, Andrew J McMichael, Bent K Jakobsen )

1999-2001 年 美国哈佛大学 / 哈佛医学院 博士后(师从 Don C Wiley, Stephen C Harrison )(工作期间资助:英国 Wellcome Trust International Travelling Fellow )

2001-2004 年 英国牛津大学 讲师、博士生导师、 Group leader

2004 -2008年中国科学院微生物研究所 所长

2004-至今 中国科学院微生物研究所 研究员、博士生导师

2008-至今 中国科学院北京生命科学研究院 副院长,中国科学院病原微生物与免疫学重点实验室 主任

2010-至今 英国牛津大学 客座教授

2011-至今 中国疾病预防控制中心 副主任

2013年12月当选中国科学院院士。

2016年5月23日,作为中国科学家当选EMBO外籍院士(会士, Associate Member)。

社会兼职/高福[中国科学院院士、中国疾控中心副主任] 编辑

2016年8月,亚洲生物技术联合会主席

2012-01--今 《Philosophical Transactions of the Royal Society B: Biological Sciences》杂志

2011-10--今 中国微生物学会病毒学专业委员会 ,副主任委员

2011-06--今 中国科学技术协会,第八届常委

2010-12--今 中国生物工程学会,第五届理事会副理事长

2010-10--今 中国免疫学会

2010-01--今 《Protein & Cell》杂志

2010-01--今 牛津大学,客座教授

2009-01--今 《Experimental Biology and Medicine》杂志

2006-06--今 国际抗病毒联盟(ICAV)

研究领域/高福[中国科学院院士、中国疾控中心副主任] 编辑

病原微生物与免疫学, 主要研究病原微生物与宿主互作及宿主免疫识别过程中相关的蛋白质结构与功能。 
分子免疫学领域:集中研究T细胞免疫中分子识别的蛋白质与蛋白质的相互作用,尤其是细胞界面的表面蛋白质(受体与配体)之间的相互作用。 

分子病毒学领域:囊膜病毒侵入的分子机制,尤其是细胞受体与病毒囊膜蛋白相互作用及融合抑制剂的药物设计。 
分子流行病学与分子进化:近几年来,联合国内其他优势单位,对野生水禽感染禽流感、人感染2型猪链球菌、猪的无名高热等传染病进行了系统研究。

科研项目/高福[中国科学院院士、中国疾控中心副主任] 编辑

(1) Follow-up of Surveillance of the Wild Birds and Pl,主持,其他级,2011-12--2012-11
(2) 新型免疫细胞δβ T细胞识别配体的功能和结构基础,主持,部委级,2011-01--2014-12
(3) 重要病毒跨种间感染与传播致病的分子机制研究,主持,部委级,2011-01--2015-12
(4) 病原微生物与宿主互作的分子机制,主持,部委级,2011-01--2013-12
(5) 获得性免疫的起源与演化,参与,部委级,2011-01--2013-12

出版信息/高福[中国科学院院士、中国疾控中心副主任] 编辑

发表论文

(1) Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4,Nature Structural and Molecular Biology,2013,通讯作者

(2) Origin and diversity of novel H7N9 avian influenza viruses causing human infecions,The Lancet,2013,通讯作者

(3) An airborne transmissible avian influenza H5 hemagglutinin seen at the atomic level,Science,2013,通讯作者

(4) Bat-derived influenza hemagglutinin H17 does not bind canonical avian or human receptors and likely uses a unique entry mechanism,Cell Reports,2013,通讯作者

(5) Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors,Nature Communications,2013,通讯作者

(6) Crystal structure of cell adhesion molecule nectin-2/CD112 and its binding to immune receptor DNAM-1/CD226,Journal of Immunology,2012,通讯作者

(7) The two-component system Ihk/Irr contributes to the virulence of Streptococcus suis serotype 2 strain 05ZYH33 through alteration of the bacterial cell metabolism.,Microbiology,2012,通讯作者

(8) The two-component system Ihk/Irr contributes to the virulence of Streptococcus suis serotype 2 strain 05ZYH33 through alteration of the bacterial cell metabolism,Microbiology,2012,通讯作者

(9) Genomic and antigenic characterization of the newly-emerging Chinese duck egg-drop syndrome flavivirus: genomic comparison with Tembusu and Sitiawan viruses,Journal of General Virology,2012,通讯作者

(10) Crystal structure of cell adhesion molecule nectin-2/CD112 and its binding to immune receptor DNAM-1/CD226,The Journal of Immunology,2012,通讯作者

(11) Structural and functional characterization of neuraminidase-like molecule N10 derived from bat influenza A virus,Proceedings of the National Academy of Sciences of the United States of America (PNAS),2012,通讯作者

(12) Analysis of drug resistance determinants in Klebsiella pneumoniae isolates from a tertiary-care hospital in Beijing, China,PLoS ONE,2012,通讯作者

(13) Type-IVC Secretion system: A novel subclass of type IV secretion system (T4SS) common existing in gram-positive genus Streptococcus,PLoS ONE,2012,通讯作者

(14) Reply to Nuclear export signal and immunodominant CD8+ T cell epitope in influenza A virus matrix protein 1--Sequence sharing between viral nuclear export signals (NES) and CD8+ T cell epitopes,Journal of Virology,2012,通讯作者

(15) Narrow groove and restricted anchors of MHC class I molecule BF2*0401 plus peptide transporter restriction can explain disease susceptibility of B4 chickens,The Journal of Immunology,2012,通讯作者

(16) An octamer of enolase from Streptococcus suis,Protein and Cell,2012,通讯作者

(17) Insights into avian influenza virus pathogenicity: the hemagglutinin precursor HA0 of H16 subtype has an a-helix structure in its cleavage site with an inefficient HA1/HA2 cleavage,Journal of Virology,2012,通讯作者

(18) Cross-allele cytotoxic T lymphocyte responses against 2009 pandemic H1N1 influenza A virus among HLA-A24 and HLA-A3 supertype-positive individuals,Journal of Virology,2012,通讯作者

(19) Genomic sequence based scanning for drug resistance-associated mutations and evolutionary analysis of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis,Journal of Infection,2012,通讯作者

(20) Insight into the interaction of metal ions with TroA from Streptococcus suis,PLoS ONE,2011,通讯作者

(21) A novel "open-form" structure of sortaseC from Streptococcus suis,Proteins: Structure, Function, and Bioinformatics,2011,通讯作者

(22) 我国发现的一种引起鸭产蛋下降综合征的新型黄病毒,中国兽医杂志,2011,通讯作者

(23) 合成病毒:对流感病毒研究的贡献,生命科学,2011,通讯作者

(24) T细胞功能学与结构免疫学结合方法鉴定HLA-A2限制性的细胞毒性T淋巴细胞表位富集区,科技导报,2011,通讯作者

(25) A strategy to produce monoclonal antibodies against gp96 by prime-boost regimen using endogenous protein and E. coli heterologously-expressed fragment,Journal of Central South University of Technology,2011,通讯作者

(26) Crystal structure of histidine-containing phosphocarrier protein from Thermoanaerobacter tengcongensis MB4 and the implications for thermostability,Science China Life Sciences,2011,通讯作者

(27) An infectious clone of the highly pathogenic porcine reproductive and respiratory syndrome virus: topology of glycoprotein 3 (GP3) addressing the intrachain disulfide bonds; PRRSV infectious clone and GP3 topology,Chinese Science Bulletin,2011,通讯作者

(28) Special features of the 2009 pandemic swine-origin influenza A H1N1 hemagglutinin and neuraminidase (invited review),Chinese Science Bulletin,2011,通讯作者

(29) Revival of the identification of cytotoxic T-lymphocyte epitopes for immunological diagnosis therapy and vaccine development,Experimental Biology and Medicine,2011,通讯作者

(30) Probing genomic diversity and evolution of Streptococcus suis serotype 2 by NimbleGen tiling arrays,BMC Genomics,2011,通讯作者

(31) Structural basis of cross-allele presentation by HLA-A*0301 and HLA-A*1101 revealed by two HIV-derived peptide complexes,Molecular Immunology,2011,通讯作者

(32) Plasticity of human CD8αα binding to peptide-HLA-A*2402,Molecular Immunology,2011,通讯作者

(33) Structural analysis of alkaline β-mannanase from alkaliphilic Bacillus sp. N16-5: implications for adaptation to alkaline conditions,PLoS ONE,2011,通讯作者

(34) Cyclophilin E functions as a negative regulator to influenza virus replication by impairing the formation of the viral ribonucleoprotein complex,PLoS ONE,2011,通讯作者

(35) LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1/LILRB2: structural evidence,PLoS ONE,2011,通讯作者

(36) Duck egg-drop syndrome caused by BYD virus, a new Tembusu-related flavivirus,PLoS ONE,2011,通讯作者

(37) Clade 2.3.2 avian influenza virus (H5N1), Qinghai Lake region, China, 2009–2010,Emerging Infectious Diseases,2011,通讯作者

(38) GI-type T4SS mediated horizontal transfer of the 89K pathogenicity island in epidemic Streptococcus suis serotype 2,Molecular Microbiology,2011,通讯作者

(39) Crystal Structure of Swine Major Histocompatibility Complex Class I SLA-1*0401 and Identification of 2009 Pandemic Swine-Origin Influenza A H1N1 Virus Cytotoxic T Lymphocyte Epitope Peptides,Journal of Virology,2011,通讯作者

(40) A large scale comparative genomic analysis reveals insertion sites for newly acquired genomic islands in bacterial genomes, BMC Microbiology,2011,通讯作者

(41) 小议2010国内外生命科学重要进展,遗传,2011,通讯作者

(42) Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition, PLoS Pathogens,2011,通讯作者

(43) Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion.,Nature Communications,2011,通讯作者

(44) Structural basis of diverse peptide accommodation by the Rhesus Macaque MHC class I molecule Mamu-B*17: insights into immune protection from simian immunodeficiency virus,Journal of Immunology,2011,通讯作者

(45) Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance,Journal of Biological Chemistry ,2011,通讯作者

(46) Two distinct conformations of a CTL epitope from rinderpest virus presented by cattle MHC class I molecule N*01801: a host strategy for presentation of a featured peptide,Journal of Virology,2011,通讯作者

(47) Diverse peptide presentation of Rhesus Macaque major histocompatibility complex class I Mamu-A*02 revealed by two peptide complex structures and insights into immune escape of simian immunodeficiency virus, Journal of Virology,2011,通讯作者

(48) Influenza A virus neuraminidase N5 has an extended 150-cavity,Journal of Virology,2011,通讯作者

(49) Enterovirus 71 and Coxsackievirus A16 3C proteases: binding to Rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design,Journal of Virology,2011,通讯作者

(50) 从人类基因组到人造生命:克雷格文特尔领路生命科学,生物工程学报,2010,通讯作者

(51) 天然免疫抗病毒效应分子Mx 蛋白的结构与功能研究进展,生物化学与生物物理进展,2010,通讯作者

(52) It is not just AIV: From avian to swine-origin influenza virus,Science China Life Sciences,2010,通讯作者

(53) In-silicon characterization of the functional and structural modules of the haemagglutinin protein from the swine-origin influenza virus A (H1N1)-2009,Science China Life Sciences,2010,通讯作者

(54) Serological surveillance of influenza A virus infection in swine populations in Fujian Province, China: no evidence of naturally occurring H5N1 infection in pigs,Zoonoses and Public Health,2010,通讯作者

(55) Identification and structural definition of H5-specific CTL epitopes restricted by HLA-A*0201 derived from H5N1 subtype of influenza A viruses, Journal of General Virology,2010,通讯作者

(56) Galanin protects against intracellular amyloid toxicity in human primary neurons,Journal of Alzheimer's Disease,2010,通讯作者

(57) Crystal structure of EHEC intimin: insights into the complementarity between EPEC and EHEC,PLoS ONE,2010,通讯作者

(58) 基于结构的抗流感病毒神经氨酸酶抑制剂的设计和研发,医药生物技术,2010,通讯作者

(59) Genetic correlation between current circulating H1N1 swine and human influenza viruses,Journal of Clinical Virology,2010,通讯作者

(60) Detection of avian influenza virus subtype H5 using a biosensor based on imaging ellipsometry,Biosensors and Bioelectronics,2010,通讯作者

(61) The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site.,Nature Structural and Molecular Biology,2010,通讯作者

(62) A dimeric structure of PD-L1: functional units or evolutionary relics,Protein and Cell,2010,通讯作者

(63) Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus,Protein and Cell,2010,通讯作者

(64) Na+/K+-ATPase β1 subunit interacts with M2 proteins of influenza A and B viruses and affects the virus replication,Science China Life Sciences,2010,通讯作者

(65) Novel immunodominant peptide presentation strategy: a featured HLA-A*2402 restricted CTL-epitope stabilized by intra-chain hydrogen-bonds from SARS-CoV N protein,Journal of Virology,2010,通讯作者

(66) Uncovering newly emerging variants of Streptococcus suis, an important zoonotic agent,Trends in Microbiology,2010,通讯作者

(67) The membrane protein of SARS-CoV acts as a dominant immunogen revealed by a clustering region of novel functional and structural defined CTL epitopes,The Journal of Infectious Diseases,2010,通讯作者

(68) Revival of gene therapy,Protein and Cell,2010,通讯作者

(69) Interspecies transmission and host restriction of avian H5N1 influenza virus,Science China Life Sciences,2009,通讯作者

(70) 动物源性流感病毒与人流感流行,科技导报,2009,通讯作者

(71) Structural insight into the catalytic mechanism of gluconate 5-dehydrogenase from Streptococcus suis: crystal structures of the substrate-free and quaternary complex enzymes,Protein Science,2009,通讯作者

(72) Stable non-synonymous substitutions on NS gene (NS1 and NS2 proteins) of Qinghai Lake H5N1 influenza virus (Clade 2.2) after successive passages in Muscovy ducks,Science China Series C: Life Science,2009,通讯作者

(73) MyBASE: a database for genome polymorphism and gene function studies of Mycobacterium,BMC Microbiology,2009,通讯作者

(74) Avian influenza virus, Streptococcus suis serotype 2, SARS-coronavirus and beyond: molecular epidemiology, ecology and the situation in China,Philosophical Transactions of the Royal Society B (Biological Sciences),2009,通讯作者

(75) Structure and cleavage-specificity of the chymotrypsin-like serine protease (3CLSP/nsp4) of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV),Journal of Molecular Biology,2009,通讯作者

(76) Crystal structures of Streptococcus suis mannonate dehydratase (ManD) and its complex with substrate: genetic and biochemical evidence for a catalytic mechanism,Journal of Bacteriology,2009,通讯作者

(77) The challenges of avian influenza virus: mechanism, epidemiology and control,Science China Life Sciences,2009,通讯作者

(78) Autophagy is involved in influenza A virus replication,Autophagy,2009,通讯作者

(79) 恒河猴MHC-I类分子Mamu-A*02与SIV抗原表位复合物的纯化和晶体学研究,生物工程学报,2009,通讯作者

(80) 鸡β2-微球蛋白及其硒代衍生物的制备和晶体学研究,科技导报,2009,通讯作者

(81) Structural immunology and crystallography help immunologists see the immune system in action: How T and NK cells touch their ligands,IUBMB Life,2009,通讯作者

(82) Crystal structure of myeloid cell activating receptor leukocyte Ig-like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes,Journal of Molecular Biology,2009,通讯作者

(83) Rhesus macaque: a tight homodimeric CD8?,Proteins: Structure, Function, and Bioinformatics,2009,通讯作者

(84) Analysis of hemagglutinin-mediated entry tropism of H5N1 avian influenza,Virology Journal,2009,通讯作者

(85) Website for avian flu information and bioinformatics,Science China Life Sciences,2009,通讯作者

发表著作

(1) 免疫学前沿进展 (第二版) 第七章: 结构免疫学研究进展: 主要组织相容性复合物的分子识别,Frontier Progress of Immunology (Edition 2) Chapter 7 Research Progress of Sructural Immunology: Molecular Recognition of Major Histocompatibility Complex ,人民卫生出版社,2011-12,第3作者

(2) 主要组织相容性复合物与多肽的相互作用,Major Histocompatibility Complex: Interaction with Peptides,John Wiley and Sons, Ltd,2011-08,第2作者

(3) 应用于健康、环境及生物安全的生物传感器 第七章:应用于人类健康的无标记生物传感器,Biosensors for Health, Environment and Biosecurity Chapter 7: Label-free Biosensors for Health Applications,InTech,2011-07,第1作者

(4) 免疫学前沿进展(第一版) 第六章: 结构免疫学研究进展: 主要组织相容性复合物的分子识别,Frontier Progress of Immunology (Edition 1) Chapter 6 Research Progress of Sructural Immunology: Molecular Recognition of Major Histocompatibility Complex ,人民卫生出版社,2009-12,第3作者科研活动

个人专利

1.CD8 as an inhibitor of the cellular immune system, PCT/GB 98/03235 (1997) (with Gerth, U.C., Sewell, A.K., Bell , J.I. and Jakobsen, B.K.).
2.Soluble T cell receptor, PCT/GB 9810759.2 (1998) (with Willcox B.E., Boulter, J.M., Bell , J.I and Jakobsen, B.K.).
3.Heat-shock protein gp96 and HBV peptide complex used for HBV-induced hepatic carcinoma, PCT/CN01/00295 (2000) (with Meng, S.-D. and Tien, P.).
4.Potent peptide inhibitors for SARS coronavirus, 2003, China application No. (with Tien, P., Zhu, J., Xiao, G. & Zheng, C.).

参与会议/高福[中国科学院院士、中国疾控中心副主任] 编辑

(1) Special characteristics of the 2009-pandemic H1N1 influenza A virus hemagglutinin and neuraminidase,2012-04,高福

(2) Nectin and nectin-like molecules: Adhesion, immune,2012-04,高福

(3) 2009 Pandemic influenza virus: what special for its HA and NA,2012-01,高福

(4) Making the CTL-epitopes featured for T cell recognition,2011国际免疫暨肿瘤研讨会,2011-12,高福

(5) 创新:永远的追求--我所认识的田波院士,第九届全国病毒学学术研讨会,2011-09,高福

(6) 分会主席,2011-09,分会主席

(7) ILT: Differential Binding to HLA,第二届海峡两岸四地免疫学研讨会,2011-08,高福

(8) T-cell-based immunotherapy,第五届中国生物产业大会,2011-06,高福

(9) 2009 Pandemic influenza virus: what special for its HA and NA,2011-06,高福

(10) Study of CTL-based cellular immunity against severe acute respiratory syndrome coronavirus,2011-06,高福

(11) 2009 Pandemic influenza virus: what special for its HA and NA,2011-01,高福

获得荣誉/高福[中国科学院院士、中国疾控中心副主任] 编辑

中国科学技术协会首届“青年科技奖”获得者( 1988 年)

北京市科学技术协会“青年优秀论文奖”获得者( 1988 年)

中国微生物学会“青年优秀论文奖” 获得者( 1989 年)

英国文化委员会与中国国家教育委员会“中英友好奖学金” 获得者( 1991 年)

英国 Wellcome Trust “International Travelling Fellow” (1998 年 )

国家自然科学基金委员会“海外青年学者合作研究基金”(杰出青年 B 类)获得者( 2002 年)

教育部“春晖计划”学术休假基金获得者( 2003 年)

中国科学院“百人计划”获得者( 2004 年)

973首席科学家( 2005年 )

国家自然科学基金委员会“杰出青年科学基金”(A类)( 2005年 )